Oxidative decarboxylative coupling reactions are emerging as an efficient route to access a diverse array of substituted arenes from inexpensive and readily available precursors. Unfortunately, many current methods suffer limitations in substrate scope and require forcing reaction conditions; a mild and general method for these transformations is needed. Our studies focus on copper mediated oxidative decarboxylative coupling reactions in an effort to expand the scope and develop an understanding of the fundamental reaction steps. We will discuss the development of a new method for decarboxylative C-H bond functionalization to generate biaryls, trifluoromethyl arenes, and other C-C bond coupled products. Preliminary mechanistic insights will also be presented.

Copper mediated oxidative decarboxylative cross-coupling reactions

248th National Meeting (2014)

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