AOEL(Acceptable Operator Exposure Levels) is used for reference dose of pesticides in operator risk assessment. In this study, the following were investigated: methods of establishment of AOEL; application of oral absorption by country; and calculation of exposure dose in operator risk assessment. AOEL was established in EU and Korea. NOAELs of short term, intermediate term, and long term study, respectively, including especially dermal or inhalation toxicity studies were used for the calculation of MOE in occupational and residential risk assessment in USA. Internal dose was used in EU and USA, but external dose to which oral absorption was not applied was used for establishment of AOEL in Korea. The lowest NOAEL of short term study including 1-year dog and reproduction study was used for establishment of AOEL in EU, but that of mainly subchronic study including only teratogenicity study was used in Korea. Internal dose of AOEL was needed to compare with exposure dose in risk assessment because internal dose was used for calculation of exposure dose with dermal absorption in EU, USA, and Korea. About 35% active substances among 143 active substances were below 80% in oral absorption. In case of application of oral absorption as a correction factor in below 80%, AOELs of about 35% active substances were considered to be lower than the previous AOELs. It was suggested that oral absorption be applied to establishment of AOEL for matching calculation of exposure dose in operator risk assessment.

Relation between application of oral absorption to calculation of internal dose in establishment of AOEL for pesticides and operator risk assessment

248th National Meeting (2014)

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