Assessments of exposure to crop protection products can be enhanced through the use of inhaled dose ADME studies. This presentation seeks to address two major concerns about such work: (i) reproducing the aerosol characteristics of large-scale batches of non-radiolabelled test compounds for the much smaller amounts of radiolabelled compound usually available when using dry powder aerosols (ii) inter-animal variability in inhalation dosing and the impact on ADME, for which accurate dose quantification is a key requisite.   The review includes data from both rodent and non-rodent studies, in which aerosols of radiolabelled test compounds have been generated from dry powders and solutions and considers ways in which ADME studies may be designed and interpreted to ensure that conclusions are scientifically robust.

Enhancing exposure assessments using inhalation ADME studies

248th National Meeting (2014)

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