In vitro and in vivodermal absorption studies are routinely performed to obtain and refine dermal absorption values for use in the risk assessment process of chemical plant protection products. Internationally agreed guidelines exist for the performance of such studies. A new guidance document for the assessment of dermal absorption (Guidance on Dermal Absorption, EFSA Journal 2012; 10(4):2665) has been developed to improve data derivation, presentation and interpretation. This guidance was produced to assist notifiers, test laboratories and Member State authorities in the aspects of the setting of dermal absorption values for risk assessment. As a result of the recommendations set out in the document, changes to the study design, data evaluation and interpretation, have become necessary. Comparison of previously used methodologies with those now employed to comply with the new guidance will be presented.

Comparison of new and old dermal methodologies

248th National Meeting (2014)

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