Historically intravenous dosing of crop protection chemicals to rats has been conducted infrequently, mainly to improve the operator exposure risk assessment for deriving an Acceptable Operator Exposure Level (AOEL). The updated EU guidelines specify that intravenous dosing should be conducted to determine systemic bioavailability unless justification can be provided for its omission. An effective intravenous dose vehicle must release the test substance without modification and without causing adverse effects to the animal. This poster summarises some of the experiences of Huntingdon Life Sciences

Determination of systemic bioavailability: Challenges and solutions

248th National Meeting (2014)

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