Proteins are notoriously unstable.  This causes protein drugs to be discarded and wasted and is inconvenient to patients.  In addition it increases shipping and storage costs for the many scientists who use proteins in their research.  This talk will focus on the application of stabilizing polymers that have trehalose in their side chains.  The trehalose glycopolymers can be either attached to the protein or simply added to stabilize the biomolecules to extreme stresses such as near boiling temperatures. The polymers significantly outperform the native sugar, trehalose as well as other gold standards in the field like poly(ethylene glycol) (PEG).  The polymers can also be made into nanoparticles to encapsulate and release proteins.  The synthesis of these polymers and their application to stabilize protein therapeutics will be discussed.

Conjugates and nanoparticles of trehalose glycopolymers stabilize protein therapeutics

248th National Meeting (2014)

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