With increasing regulatory demands, agricultural companies are looking for more efficient ways of analyzing thousands of soil and crop samples. Rapid analysis with high sample throughput could be utilized to complete the analysis within a very short time. This increase of productivity and efficiency is a continual goal for lab managers. This goal has led to the development of cost effective micro methods using sample sizes as little as 0.1 g in a 96-well plate. The biggest challenge to apply this technology has been to effectively prepare a representative agricultural sample while reducing the size of the sample to fit into a well plate. Sample homogeneity was tested by analyzing different aliquot weights from different field- treated plants/soil matrices. High sample throughput was achieved by implementation of miniaturization (~0.1 g sample size) and automation (automated solvent delivery system) . Samples were analyzed for active ingredients and their metabolites using LC/MS/MS for final residue determination. The details, including some case studies, will be discussed in this presentation.

High sample throughput � size does matter or does it � case studies: How to verify that your homogenization technique is adequate for your demands

248th National Meeting (2014)

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