As the amount of sample used for residue analysis decreases due to increasingly sensitive instrumentation and the incorporation of automation, the sample preparation step becomes ever more critical. In residue analysis, the initial sample size may vary from a few grams to several kilograms. In order to obtain accurate results, the processed sample must be sufficiently homogenous, such that a 100 mg aliquot will be representative of the initial bulk sample. This presentation will focus on results obtained from a round-robin style sample preparation assessment performed across three independent laboratories. Initial milling was performed at the source lab, and subaliquots were shipped to the independent labs for further processing by cryomilling. The samples were returned to the source laboratory for analysis. The resulting sample concentrations were evaluated for consistency of data across laboratories, matrices or compound tested.

Inter-laboratory assessment of cryomilling sample preparation for residue analysis

248th National Meeting (2014)

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