The current approach utilized for ecological effects testing and risk assessment consists of a flexible and robust framework that can accommodate a science-based assessment of a variety of pesticidal products with different modes of action. A hypothesis�based approach, consistent with the existing risk assessment paradigm, was developed to characterize the activity spectrum and inform the ecological risk assessment for a maize product expressing a dsRNA targeting the Snf7 ortholog (DvSnf7) in Western Corn Rootworm (Diabrotica virgifera virgifera) and the Cry3Bb1 protein. This presentation provides an overview of the activity spectrum, bioinformatics analysis, interaction assessment between Snf7 and the Cry3Bb1 protein, and the results from the effects testing program put into the context of an ecological risk assessment. Based on this assessment, the DvSnf7 RNA is shown to be highly specific and is not likely to produce adverse effects on terrestrial beneficial invertebrate species at field exposure levels.

Ecological risk assessment for an RNAi plant incorporated protectant

248th National Meeting (2014)

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