With the purpose of extending our efforts on designing and synthesizing new insecticides with novel modes of action, a series of novel 4-(2-(4-(pyridin-2-yl)piperazin-1-yl)ethoxy)aniline derivatives were designed based on classical serotonin receptor ligands and synthesized through a functionalized ionic liquid support parallel synthesis method with yields up to 88%. These products were purified through convenient washing with appropriate solvents and isolated in good yield. In addition, a series of amide or urea derivatives of those anilines were also prepared. Bioassay data showed that some of the synthesized compounds displayed nematicidal activity.

Functionalized ionic liquid-supported synthesis of piperazine derivatives as potential nematicides

248th National Meeting (2014)

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