Chemoselective reactions for amide bond formation have transformed the ability to access synthetic proteins and other bioconjugates through ligation of fragments. In these ligations, amide bond formation is accelerated by transient enforcement of an intramolecular reaction between the carboxyl and the amine termini of two fragments. Building on this principle, this talk will describe an auxiliary-based approach called �aldehyde capture ligation (ACL)� that parlays the chemoselective reactivity of aldehydes and amines to enforce amide bond formation between unprotected peptide segments. This talk will demonstrate the application of ACL in synthesis of hybrid materials.

Aldehyde capture ligation: A chemoselective approach to peptides and bioconjugates

248th National Meeting (2014)

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