The secreted Wnt signaling molecules are essential to coordinated cell fate decision-making in developing and post-embryonic metazoans. Wnt ligand-dependent and �independent signaling is frequently exploited in a broad range of maladies that affect adult tissue homeostasis including cancer and aging. We discuss our efforts to delineate the mechanism of action for novel small molecules that disrupt Wnt signaling identified from a high throughput screen in cultured cells. We also present our progress in matching these chemical discoveries to therapeutic discovery agendas.

Leveraging developmental and cancer genetics to drug the Wnt pathway

248th National Meeting (2014)

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