This presentation will discuss the discovery and development of catalytic technologies to enable the efficient preparation of HCV polymerase inhibitors. The development of new catalytic methods was driven by the need for higher efficiency in the synthesis as well as for the need to avoid certain reagents or byproducts, such as genotoxic impurities (GTIs). A Cu-catalyzed C-N cross-coupling reaction was employed to N-arylate uracil in high yield and exceptional regioselectivity.

Discovery of novel catalytic technologies in the process development of HCV polymerase inhibitors

248th National Meeting (2014)

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