Herein we present a web server, CONSRANK, as a web interface for a series of tools we developed for the analysis and ranking of protein-protein and protein-nucleic acid docking models.1-4 CONSRANK takes as input a set of PDBs in an archive file (.tar, .zip), and gives as output: i) a list of observed inter-residue contacts in the models ensemble with relative conservation rate; ii) values of parameters reflecting overall conservation of inter-residue contacts in the models ensemble; iii) the ranking of the models based on their ability to match the most conserved inter-residue contacts. Furthermore, CONSRANK gives as output a �consensus map�, i.e. an intermolecular contact map where the conservation of inter-residue contacts is reported on a gray scale. This is an interactive map that can be zoomed and navigated to visualize the identity of the residue pairs corresponding to a given contact and its conservation rate. An interactive 3D representation of the consensus map, where the third dimension is given by the conservation rate of each inter-residue contact is also provided. By clicking on a specific model, further analyses will be performed on it and 2D and 3D inter-molecular contact maps will be generated and visualized superimposed to the consensus ones.References1) Vangone, A.; Spinelli, R.; Scarano, V.; Cavallo, L.; Oliva, R. Bioinformatics 2011  27, 2915.2) Vangone, A.; Oliva, R.; Cavallo, L. BMC Bioinformatics 2012 , 13, S19.3) Oliva, R., Vangone, A. and Cavallo, L. Prot. Struct. Func. Bioinf. 2013 , 81, 1571. 4) Vangone, A., Cavallo, L. and Oliva, R. Prot. Struct. Func. Bioinf. 2013 , 81, 2210.

CONSRANK: A web tool for the analysis and ranking of docking models

248th National Meeting (2014)

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