CARES� refers to the Cumulative and Aggregate Risk Evaluation System, of which several versions were developed from 2001-2011.  The last version, CARES V.3.0, represented a then state-of-the-art software program designed to conduct complex human exposure and risk assessments, such as the aggregate and cumulative exposure and risk analyses required for pesticides under the Food Quality Protection Act. CARES represents a population- and calendar-based probabilistic model that attempts to simulate a �realistic� estimation of overall exposure to the US populations of interest by integrating information from multiple databases. The US EPA expressed the need to revise CARES for their use, and use by other stakeholders, particularly for advanced probabilistic modeling, e.g., the upcoming pyrethroid cumulative risk analysis. In addition, the PC-based system was becoming cumbersome and expensive to maintain as new operating versions emerged and other new databases needed to be incorporated into the system. In response to the major updates required for advancing the state of the science and data supporting CARES, and to maintain the relevance of the program, a new project and task force was assembled in late 2013 to develop the new system, CARES-Next Generation (NG).  The next version of the software will be a cloud-based application, containing updated exposure models, databases and functionality. In particular, updated food consumption information from the NHANES �What We Eat in America� database (2003-2008) and the EPA's updated Standard Operating Procedures for residential exposure assessment will be incorporated. The key elements of this cloud based CARES-NG, progress toward CARES-NG availability and its strengths and weaknesses compared to CARES V.3.0 and other pesticide regulatory exposure models will be presented.

Cumulative Aggregate Risk Evaluation System (CARES): The next generation

248th National Meeting (2014)

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