Currently, 25.8 million people in the United States are living with diabetes. This comprises 8.3 % of the American population1. Therefore, research for improved glucose detection is an area of significant clinical importance that demands inexpensive, effective in methods of testing blood glucose levels. It has been reported that glucose can reduce noble metals such as silver and gold to form nanoparticles in solution2,3. Herein, we report direct colorimetric detection of glucose in the physiological range through the reduction of silver nitrate and tetrachloroauric acid yielding silver and gold nanoparticles respectively. Glucose concentrations are detected through changes in solution color that is visible to the naked eye. The Au and Ag nanoparticles are characterized by UV/visible spectroscopy and transmission electron microscopy. In addition to measuring purified glucose solutions, samples of mouse serum containing glucose were also measured. The nanoparticles were then integrated onto a surface using nanosphere lithography substrates (NSL) for further analysis and characterization. Through this method, we conclude that we are able to directly detect glucose in both the healthy physiological range from 3 � 7 mM, and the high glucose range = 11.1 mM.'Diagnosing Diabetes and Learning About Prediabetes: American Diabetes Association�.'American Diabetes Association.Qin, G. W., et al. (2008). 'A Facile and Template-Free Method to Prepare Mesoporous Gold Sponge and Its Pore Size Control.' The Journal of Physical Chemistry C 112  (28): 10352-10358.Pan�c?ek, A., et al. (2006). 'Silver Colloid Nanoparticles:? Synthesis, Characterization, and Their Antibacterial Activity.' The Journal of Physical Chemistry B 110  (33): 16248-16253.

Nanoparticle formation for colorimetric glucose detection

248th National Meeting (2014)

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