While solid-phase synthesis has made the generation of native RNA and DNA polymers trivial, modified derivatives are not so simple. I will present the various strategies we have been developing to create chemically tailored RNA derivatives. These range from new phosphoramidates for solid-phase synthesis to direct chemical modifications on native RNA and DNA polymers. Although the commercial production of therapeutics will almost certainly be achieved through standard solid-phase synthesis, at the screening and optimization stage modular chemical strategies to create libraries of nucleic acid derivatives would be valuable.

New convergent approaches to therapeutically relevant RNA derivatives

248th National Meeting (2014)

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