Cycloxaprid is a novel neonicotinoid under development in China. Its unique oxabridged structure makes it different from other types of neonicotinoids. It showed outstanding activities against a variety of homoptera and lepidoptera insects. Moreover, it exhibited 30- to 100-fold higher bioactivity against resistant insects, such as Nilaparvata lugens and Bemisia tabaci. 25% Cycloxaprid WP and 70% Cycloxaprid WD has been developed for pest control. Cycloxaprid is traditionally prepared from the nitromethylene analogue of imidacloprid (NMI) and succinaldehyde. For lowering the cost, a new environment-friendly preparation method has been developed. Metabolism studies indicated that it might serve as a slow-release reservoir for NMI. It had different biding sites with imidacloprid on Nilaparvata lugens nAChRs. Further process optimization, MoA, metabolism and formulation study is in progress.

Cycloxaprid: A novel insecticide with unique properties

248th National Meeting (2014)

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