The incidence of mosquito-vectored human disease is increasing throughout the world, with effective chemical control interventions limited due to widespread insecticide resistance. Recent evidence suggests that bacterial symbionts of mosquitoes, known to be essential in nutritional homeostasis and pathogen defense, may also play a significant role in facilitating mosquitocide resistance. Here, we examined the capacity of bacterial symbionts to modify the metabolic detoxification of mosquitocidal chemistries and, thus, alter the toxic action of these chemistries towards the dengue mosquito, Aedes aegypti. These data will be discussed with regard to the role of bacterial symbionts as a resistance barrier to the target-site delivery of mosquitocidal chemistries and the importance of these bacterial symbionts in pharmacokinetic and pharmacodynamic studies for the increased efficacy of mosquitocidal chemistries for vector management.

Symbiont-mediated modification of mosquitocide toxicity

248th National Meeting (2014)

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