Development of environment-friendly formulations for poorly water-soluble pesticides remains an arduous challenge. As a potential pesticide carrier of deltamethrin (DM), hydrophobic octa-hydrogenated retinoic acid (OR) was chemically conjugated to glycol chitosan (GC) polymer for solubilizing the poorly water-soluble pesticide. By this means amphiphilic octa-hydrogenated retinoic acid-glycol chitosan (OR-GC) conjugates effictively encapsulated deltamethrin (20 wt.%) with a maximum drug loading efficiency of 47%. Freshly prepared DM-OR-GC nanoparticles had an average diameter of 332 nm and were stable in aqueous solution. The DM from nanoparticles exhibited a sustained release profiles. From cytotoxicity tests, it was confirmed that DM-OR-GC nanoparticles showed good inhibition of proliferation effect on Spodoptera litura ovarian cells (Sl-1) compared with free DM in organic solvents. Overall, DM-OR-GC nanoparticles might be a promising carrier for deltamethrin delivery in pesticide formulations.

Controlled release and in vitro cytotoxicity of self-assembled glycol chitosan nanoparticles as a pesticide carrier for deltamethrin delivery

248th National Meeting (2014)

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