Photoactivatable (caged) fluorophores are critical tools for advanced microscopy experiments. Numerous strategies have been developed to prepare fluorogenic molecules that release bright fluorophores with wavelengths that span the visible spectrum and beyond. Despite these advances, little progress has been made in improving the biological compatibility of the caging groups. In this work, alterations of the caging groups is undertaken to improve the solubility of the caged fluorophores to improve their performance in cellular imaging assays.

Improving caging groups for fluorophores: Enhancing performance in cellular imaging assays

248th National Meeting (2014)

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