Transformations that entail catalytic generation of reactive entities for in situ use in stereoselective synthesis are in high demand. Such processes are more efficient and operationally simpler than when a priori preparation and purification of stoichiometric quantities of sensitive intermediates are required. We have designed and developed a new class of multi-component tranformations that are promoted by one catalyst chemo-, site- and stereoselectively via catalytic generation of 2-boron-substituted allylcopper intermediates. The utility of this method is highlighted in bioactive natural product synthesis.

Cu-catalyzed chemoselective synthesis of 2-boron-substituted allylcopper complexes and their in situ site-, diastereo- and enantioselective additions to carbonyls

248th National Meeting (2014)

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