Magnetic Resonance Imaging (MRI) is a widely used clinical diagnostic method and 40 % of the MRI scans use a contrast agent, generally gadolinium based. Linear Gadolinium MRI contrast agents (DTPA) have been associated with the development of Nephrogenic Systemic Fibrosis (NSF) and all current agents have much lower sensitivity than theoretically possible. We seek the development of complexes with higher relaxivity than commercial contrast agents that are also kinetically inert with regard to Gd release. Hydroxypyridinone (HOPO) based ligands have high thermodynamic stability, higher water exchange rates and increased total number of coordinated water molecules. The bi-macrocyclic complexes are predicted to have excellent kinetic stability, which will be verified by relaxivity studies. This poster will present a molecular modeling study of bi-macrocycle revealing an optimum sized cavity for gadolinium coordination, synthesis and characterization of the lead compound.

Synthesis of macrocyclic MRI contrast agents

248th National Meeting (2014)

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