Transition metal-catalyzed cross coupling has revolutionized the way that chemists assemble carbon�carbon (C�C) bonds. These reactions typically involve aryl or alkyl (pseudo)halide electrophiles, which represent a small subset of the reaction partners used in organic synthesis. Our laboratory is interested in developing new cross-coupling reactions with classic aliphatic electrophiles in organic synthesis, including epoxides, aziridines, N,O-acetals, and acetals. This lecture will describe some of our recent progress in this area involving methodology development, mechanistic investigations, and applications that permit modular and efficient access to enantioenriched amines and ethers.

New electrophiles for nickel-catalyzed cross coupling

248th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.