The concept of cooperativity in catalysis arises when two or more catalysts synergistically provide rate enhancement of chemical reactions. We have designed such catalytic system (based on Lewis acids and Br�nsted acids) for the activation of unreactive substrates. Despite the use of Lewis acids and Br�nsted acids in myriad of organic transformations, a clear understanding of solution structures of substrate-catalyst complexes is lacking. We have used advanced NMR experiments to characterize the solution structures of intermediates involved in cooperative-catalytic systems developed in our lab. Results from these experiments will be presented.

Cooperativity in catalysis: Understanding modes of activation of unreactive substrates

248th National Meeting (2014)

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