Continued exploration of the rhodium-catalyzed intramolecular carboacylation of quinolinyl ketones and tethered alkenes has prompted the investigation into intermolecular cross-coupling reactions. Proceeding through a similar intermediate generated from C-C bond activation, a variety of rhodium catalysts, directing moieties, and transmetallating reagents were screened in pursuit of the selective activation and functionalization of substituted ketones. Apart from investigating the functional group tolerance of the reaction, current work is being done to optimize reaction conditions as well to develop facile sp2-sp3 cross-coupling pathways.

Development of intermolecular cross-coupling reactions proceeding via rhodium-catalyzed C-C bond activation

248th National Meeting (2014)

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