 Palladium(0)-catalyzed conditions for the a-arylation of sultams with aryl and heteroaryl iodides have been developed. Arylation of 3-substituted 1,3-propanesultams gives rise to high yields and high diastereomeric ratios, leading to the thermodynamically favored cis product. The arylation is broadly applicable to various of electron-rich and electron-poor (hetero)aromatic iodides.

Pd-catalyzed a-arylation of sultams with aryl and heteroaryl iodides

248th National Meeting (2014)

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