The brain requires among the highest levels of metals in the body, including redox-active transition metals like copper and iron, as well as the body's highest need for oxygen consumption. However, misregulation of these same metal pools and associated oxidative stress are major players in aging and neurodegeneration. We are creating and applying new chemical tools to study metals and small-molecule signal/stress agents in neural systems by molecular imaging. This talk will present our latest results on developing new molecular imaging agents and their use in live cell, tissue, and animal settings.

Molecular imaging approaches to studying redox-active signaling in the brain

248th National Meeting (2014)

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