Cyazypyr� (cyantraniliprole) and Rynaxypyr� (chlorantraniliprole) belong to the diamide class of insecticides which are ryanodine receptor activators. To-date, no studies have been reported demonstrating the action of diamides at the single-channel level. Here we describe the effects of Cyazypyr� on the human cardiac ryanodine receptor reconstituted in a lipid bilayer. These studies show that Cyazypyr� increases the frequency of open channel gating of the ryanodine receptor in a calcium-dependent manner. Earlier studies conducted on mammalian cell lines found Cyazypyr� to be highly selective for insect over mammalian receptors. Similar findings were observed at the single-channel level with human cardiac ryanodine receptors.

Ryanodine receptor single-channel study of the diamide insecticide, Cyazypyr�

248th National Meeting (2014)

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