RNA interference (RNAi) is a natural mechanism used by different organisms for natural defense and gene regulation, utilizing a highly specific sequence recognition process.  RNAi for pest control makes it possible to precisely target critical genes in a pest, leading to a directed pesticidal effect and ensuring safety to non-target organisms such as the honey bee.  We present data from laboratory feeding studies with honey bees that demonstrate dsRNAs targeting the pest species, Varroa destructor and Corn rootworm (Diabrotica virgifera virgifera), did not adversely affect honey bee survival, growth or development.   Relevant test methods for assessing the potential for adverse effects of pesticidal dsRNAs on both larval and adult stages of Apis mellifera are discussed.

RNAi and honey bees: Specificity and safety

248th National Meeting (2014)

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