Herbicide safeners are a group of agrochemicals which enhance herbicide tolerance of crops. The protective effect of safener R-28725 (3-dichloroacetyl-2,2-dimethyl-1,3-oxazolidine) and other three different chiral N-dichloroacetyl oxazolidine derivatives were studied by physiological and biochemical tests. The results showed that the growth level and some physiological index of maize were inhibited by chlorsulfuron and recovered by all the compounds. R-28725 and compound A [(R)-3-dichloroacetyl-2,2-dimethyl-4-ethyl-1,3-oxazolidine] showed better protection than others. Both of them could enhance the glutathione (GSH) content and glutathione-S-transferase (GST) activity (in vivo and in vitro). R-28725 and compound A increased GST activity in maize, and accelerated chlorsulfuron detoxification through conjugation with GSH. This is one of the elementary detoxified pathways by safener in crops. Meanwhile, acetolactate synthase (ALS) activity, the herbicide target enzyme, was also increased, which indicated that both of the compounds stimulated ALS activity and led to detoxification of chlorsulfuron.

Protective responses induced by <i>N</i>-dichloroacetyl oxazolidine safeners in maize

248th National Meeting (2014)

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Protective responses induced by N-dichloroacetyl oxazolidine safeners in maize