Regulations in the crop protection industry are becoming more stringent and the acute toxicity profile is becoming a relevant driver for formulations development. The use of non-animal toxicity screening, together with a novel formulation technology approach, increases the level of confidence to deliver crop protection formulations without critical acute toxicity effects like skin sensitization. The KeratinoSens� assay has emerged as one of the most promising in vitro assays for predicting skin sensitization potential. In an earlier study, this method demonstrated good performance for crop protection active ingredients and their corresponding agrochemical formulations. The application of the KeratinoSens� assay and modern formulation technology, to successfully deliver a non-skin sensitizing, high-load formulation of a documented skin sensitizing active ingredient, while keeping economical levels of biological activity, is exemplified in this study.

Application of the KeratinoSens� assay for assessing the skin sensitization potential to support crop protection formulations development

248th National Meeting (2014)

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