Cancer is a systemic disease that affects the metabolism causing general worsening health status of oncologic patient. Therefore malnutrition is a process that adds to cancer as a side effect being either the disease or treatment. Some parameters altered cannot be detected when evaluated by the conventional method (spectrophotometry). Among the various techniques, we can mention one of the nonlinear optic which is the Z -Scan technique as a promising tool for the analysis of biochemical parameters used for clinical evaluation in oncologic patients. This study aimed to compare the Z -Scan methods and spectrophotometry in samples of children with leukemia and solid tumors supplemented with selenium. Patients with leukemia and solid tumors were included and supplemented with selenium. Approximately 5.0 ml of whole blood were obtained by venipuncture. Serum was separated by centrifugation. The parameters glucose, total cholesterol and triglycerides were determined by enzymatic colorimetric method by spectrophotometry and the Z-Scan method at different stages of supplementation with selenium. Our results suggest the importance of selenium in the control of metabolic changes in cancer patients and in addition the Z scan method was related to the conventional method in the proposed regulations. Supported by FAPESP (grant n. 2012/13871-7), CNPq and INCT-FCx.Ethics Committee (process:05139812.9.0000.0082)Keywords: Z-Scan technique, neoplasm in infants and children, biochemical parameter, selenium

Determination of biochemical parameter in children with leukemia and solid tumors supplemented with selenium by Z-Scan technique

248th National Meeting (2014)

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