In recent years, there has been an increasing interest in the field of natural phenolics. That interest apparently arises from the growing awareness and concern at all levels of society of the importance of natural products in general, but specifically on natural phenolics.Plant phenolics, especially flavonoids, are currently of growing interest owing to their supposed functional properties in promoting human health. As a part of our continuing search among medicinal plants cultivated in Egypt for flavonoid constituents, which might possess biological activity. All structures were determined by conventional method of analysis and confirmed by FT-MS and NMR studies.Interpretation of the data of 1-D 1H and 13C NMR, together with 2D-homo- and hetero-nuclear chemical shift correlation NMR is discussed to confirm the configuration and conformation of the sugar core of each compound. Isolation of The compounds 3,6 � O � Hexahydroxy-diphenoly - (a/b) -1C4 - glucopyranose; 1-mono-O-galloy-3,6-O-Hexahydroxydiphenoly-(b)-B1,4-glucopyranose;1,4-di-O-galloy-3,6-O-Hexahydroxy-diphenoly - (b) - B1,4 � glucopyranose ; 1,2,4-tri-O-galloy-3,6-O-Hexahydroxy- diph enoly - (b)-B1,4-glucopyranose were isolated from the leaves of Punica granatum. The report was disproved later, however, merits of this fruit remained yet; clinical efficacy for preventing and remediating cancers including breast and prostate cancers by oral administration of the juice, seed oil, and peel extract is still believed to be true. In this review, target components of pomegranate such as antioxidants, anti-cancers, antiestrogens and ethnomedical components were analyzed and discussed along with examining its pharmaceutical efficacy and prescription to postmenopausal lesion, cardiosclerosis, cosmetic beautification, viral and allergic symptoms, and diabetes mellitus, etc.The leaf extracts were used to test the antimicrobial activity against bacteria. The chemistry and biology of natural phenolics must now considered to be an important research area.This could be recognized from the fact that although a surprisingly several natural phenolics have interesting pharmacological properties, yet the number of commercially successful phenolic drugs from natural resources remains small.

Punica granatum as antioxidants, anticancers, antiestrogens, ethnomedical, and isolated of phenolic components

248th National Meeting (2014)

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