Recently, selenium nanoparticles (SeNPs) have become a new research target, since they were found to possess excellent bioavailability, low toxicity and remarkable anti-cancer activity. Nevertheless, SeNPs aggregate easily and their anti-cancer activity will be signifcantly reduced, once their nano-size could not be maintained. This limiting factor greatly hinders their development into novel health food products. By using the water soluble polysaccharide-protein complex isolated from tiger milk mushroom sclerotia, we have successfully prepared highly stable, size controllable SeNPs under a simple, �food grade� redox system. Interestingly, these novel SeNPs were found to significantly inhibit the growth of human breast cancer cells via apoptosis induction both in vitro and in vivo. Our long term goal is to develop SeNPs into an economical, safe and evidence-based health food product for our community, hereby alleviating the now spiraling cost of cancer treatments in the local public healthcare system.

Preparation of novel selenium nanoparticles with strong in vitro and in vivo anticancer efficacy using tiger milk mushroom

248th National Meeting (2014)

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