We have employed gold nanoparticles (AuNPs) as building blocks for self-assembled delivery vehicles.  These studies have used AuNPs to stabilize oil-in-water emulsions, providing nanoparticle-stabilized capsules (NPSCs) (Figure 1). Through appropriate choice if particle functionality and oil we have been able to generate ~100 nm capsules. These capsules are stable in serum, with in vitro cell studies indicationg effective delivery of hydrophobic drugs. More recently, these capsule have been used to deliver both proteins and siRNA directly to the cytosol, avoiding the myriad challenges faced with endocytotic strategies. 

Nanoparticle-stabilized nanocapsules for direct delivery of proteins and siRNA to the cytosol

248th National Meeting (2014)

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