Nonbonding interactions between atoms are crucial to stabilizing and directing molecular formation in solutions and solids.  Interactions such as hydrogen and halogen bonding have been studied to elicit these stabilizing and directing features.  Another interaction, the carbon bond, also has similar capabilities and could prove to be essential in many molecular interactions, specifically in drug design. A quantitative evaluation was performed using the Cambridge Structural Database (CSD) and protein database (PDB)to analyze the carbon bond interaction.  The search criterion was based upon van der Waals radii distances and avoidance of weak hydrogen bonds.   This allowed us to measure the interactions between the carbon atom and nucleophile.  The molecular configurations that were searched in the CSD were F/O/Cl-C�N/O/S/Cl/F. The O-C�O species yielded the greatest amount of hits at 39066.  The F-C�S species generated only 125 hits. The statistical analyses of the results are presented.

Carbon bond: A noncovalent interaction

248th National Meeting (2014)

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