Amphiphilic block copolymers containing hydrophilic polyoxazoline blocks is very useful for biomedical applications. Macroinitiation is the common method ofsynthesizing these polymers. However, macroinitiation results in low yields and block lengths are difficult to control. We have recently shown a modular method of synthesizing well defined triblock copolymers consisting of polyoxazoline-polysiloxane-polyoxazoline using copper catalyzed click chemistry. However, the stealth property of these polymers diminishes when synthesized via copper catalyzed click. We have recently investigated copper free methods for synthesizing these polymers and these polymers show that polyoxazoline is a viable alternative to PEG for drug-delivery.

Polyoxazoline block copolymers: Synthesis and applications

248th National Meeting (2014)

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