Isocyanide based multicomponent reactions (IMCRs) are very efficient atom-economical reactions that can assemble three or more different components into one molecule in a one-pot process, and have therefore been playing important roles in many fields. Among the IMCRs, Passerini reaction, a three component reaction first described in 1921, has been proved to be a powerful synthetic method that can yield an ester-amide linkage from a carboxylic acid, an aldehyde and an isocyanide. It is thus quite advantageous to use this reaction to prepare polymers with different architectures and functional groups in a very efficient and straightforward way. Unfortunately, this highly efficient reaction has been overlooked for a long time in polymer synthesis; only until quite recently, synthesis of polyesters by this reaction has been reported. We extended the scope of Passerini reaction in polymer science as a green multicomponent polymerization method. In this talk, I will describe several synthetic approaches to different functional polymers, which will include linear poly(ester-amide), polyamides,star polymers, graft copolymers, photo-degradable polymers, self-degradable polyesters, and hyperbranched polymers and dendrimers.

Multicomponent polymerization as a green polymerization method for precision polymer synthesis

248th National Meeting (2014)

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