Transition metal catalyzed C-H functionalization has attracted considerable attention due to its step- and atom-economic feature in organic chemistry. Compared with the efficiency of direct (hetero)aryl C-H bond functionalization reactions, direct alkene-alkene coupling reactions involving alkenyl C-H bond activation are rarely reported. This paucity is primarily due to the inertness of the C-H bond in simple olefins, and the difficulties in promoting the desired cross-coupling while avoiding homocoupling. Herein, we report our recent progress in converting the simple alkenes into various high values compounds via palladium(II) or copper(I) catalyzed vinylic C-H functionalization of alkenes or enamides.References1.   (a) Y. H. Xu, J. Lu and T. P. Loh, J. Am. Chem. Soc., 2009 , 131, 1372; (b) Z. K. Wen, Y. H. Xu and T. P. Loh, Chem.�Eur. J., 2012 , 18, 13284; (c) Z. K. Wen, Y. H. Xu and T. P. Loh, Chem. Sci., 2013 , 4, 4520.2.   (a) H. Zhou,W. J. Chung, Y. H. Xu, T. P. Loh, Chem. Commun. 2009 , 3472; (b) H. Zhou, Y. H. Xu, W. J. Chung, T. P. Loh, Angew. Chem. Int. Ed. 2009 , 48, 5355.3. (a) Y. H. Xu, Y. K. Chok and T. P. Loh, Chem. Sci., 2011 , 2, 1822; (b) S. Pankajakshan, Y. H. Xu, J. K. Cheng, M. T. Low, and T. P. Loh, Angew. Chem. Int. Ed. 2012 , 51, 5701; (c) C. Feng, T. P. Loh, Chem. Sci., 2012 , 3, 3458.

C-H functionalization of alkenyl SP2 C-H bonds

248th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.