Mechanochemical activation, conducted by milling or grinding has proven to be a clean, energy-efficient alternative to carry out syntheses of organic and inorganic compounds, coordination polymers and porous frameworks.1 Inspired by recent development in mechanochemical strategies for organic solvent-free synthesis, we have recently demonstrated2 a mechanochemical route to conduct oxidative addition, one of the fundamental reactions of organometallic chemistry. This reactivity is orthogonal to mechanochemical ligand exchange processes, allowing for the first time the exploration and design of multi-step and multicomponent synthetic organometallic procedures using milling synthesis to derivatize rhenium and manganese carbonyl complexes (M2(CO)10M=Re, Mn), reducing the use solvent, energy and time during the work up stages, to enhance the green qualities of mechanochemical protocols.Figure 1 . Multistep-mechanochemical organometallic synthesis.References 1. James, S. L.; Adams, C. J.; Bolm, C.; Braga, D.; Collier, P.; Fri�cic, T. et al. Chem. Soc. Rev. 2012  , 41, 413-447.2. J. G. Hern�ndez, N. A. J. Macdonald, C. Mottillo, I. S. Butler and T. Fri�cic. Green Chem. 2014  , 16, 1087-1092.

Multi-step and multi-component organometallic synthesis using mechanochemistry

248th National Meeting (2014)

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