Tumor-associated carbohydrates were discovered more than 30 years ago and have been used in a variety of studies as haptens for anticancer vaccine design. In addition, some of these small saccharides have been directly implicated in the metastatic process of different solid tumors. We have concentrated on the Thomsen-Friedenreich disaccharide as a basis for the synthesis of nanoparticles containing this antigen in a range of presentations. This talk will highlight our latest in vitro and in vivo results where only specific presentations show interesting activity. The utility of these constructs as imporatnt anti-tumor tools and potential therapeutic agents wiil be discussed.

Glycopeptide conjugates of tumor-associated carbohydrate antigens as anticancer agents

248th National Meeting (2014)

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