Novel structurally simple 1-thio-�-D-glucopyranosides were synthesized and tested as potential inhibitors towards several fungal glycosidases from Aspergillus oryzae and Penicillium canescens. Significant selective inhibition was observed for a- and �-glucosidases, while the same compounds produced a weak to moderate activation of a- and �-galactosidases.

Thio-�-D-glucosides: Synthesis and evaluation as glycosidase inhibitors and activators

248th National Meeting (2014)

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