Tumor associated carbohydrate antigens (TACAs) are overexpressed on tumor cells, which renders them attractive targets for anti-cancer vaccines. To overcome the poor immunogenecity of TACAs, we designed and synthesized a polymer platform via controlled polymerization for antigen presentation by taking advantage of the polymeric backbone to incorporate different immunoactive components on the same chain in order to elicit robust T cell dependent immune response. Immunology studies were carried out to evaluate the efficacy of the glycopolymer as a potential cancer vaccine.

Glycopolymer platform for presentation of tumor associated carbohydrate antigens

248th National Meeting (2014)

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