The use of aluminum tris(2,6-di-2-napthylphenoxide) (ATNP) in a vinylogous aldol reaction between a furoate ester and various aldehydes and ketones will be described. The reaction takes advantage of the large bulk of ATNP in order to selectively react at the e-position of the ester allowing access to novel products via a new bond formation. The diastereoselectivity of this reaction is explored using a and � substituted aldehydes.

Vinylogous aldol of furoate esters with enolizable aldehydes and ketones using aluminum tris(2,6-di-napthylphenoxide)

248th National Meeting (2014)

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