In this contribution, selected examples of the properties and use of poly(2-oxazoline) (POx) as very promising polymer therapeutics will be presented [1-9]. This will include the use of amphiphilic POx triblock copolymers as high-capacity drug delivery systems (DDS) for hydrophobic drugs such as paclitaxel [7] and others [2], exhibiting synergistic effects for the delivery of multiple chemotherapetic drugs. The talk will focus on the reasons for the unparalleled high drug-loading capacities of the POx system and outline the consequences of the drug loading on the DDS morphology [9] and anticancer efficiacy found in recent preclinical studies. Acknowledgement. This work is supported by the National Cancer Institute Alliance for Nanotechnology in Cancer through the National Institutes of Health grant to the Cancer Nanotechnology Platform Partnership (U01 CA116591).(1) Luxenhofer, R. et al. Macromol. Rapid Commun. 2012, 33, 1613.(2) Han, Y. et al. Mol. Pharmaceutics 2012, 9, 2302(3) Gaertner, F. C. et al. J. Control. Release 2007, 119, 291.(4) Tong, J. et al. Mol. Pharmaceutics 2010, 7, 984.(5) Tong, J. et al. Biomaterials 2011, 32, 3654.(6) Luxenhofer, R. et al. J. Control. Release 2011, 153, 73.(7) Luxenhofer, R. et al. Biomaterials 2010, 31, 4972.(8) Manzenrieder, F. et al. Angew. Chem. Int. Ed. 2011, 50, 2601.(9) Schulz, A. et al. ACS Nano 2014, 8, 2686.

Poly(2-oxazoline)s for drug-delivery

248th National Meeting (2014)

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