Microfluidics has evolved from initially a scale-dependent chemical analysis technology towards a versatile platform that opens up new opportunities to addressing the challenges in biology and medicine. In particular, it provides a powerful tool to promote quantitative and systems analysis of molecular and cellular events in complex biological systems. In this presentation, I will discuss the design and implementation of integrated microfluidic systems for quantitative molecular and cellular analysis down to the single cell/copy levels with high throughput. Their applications to high-performance detection of cancer-associated biomarkers, such as genetic mutations and glycoproteins, will be demonstrated. These results would suggest the feasibility of translating these microfluidics-enabled biotechnologies into biomedical and clinical investigations.

High-performance biomedical analyses using integrated microfluidic systems

248th National Meeting (2014)

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