Recently, we have developed a new DNA array platform that is formed electrochemically and addressed using a secondary electrode.  Electrochemical activation of a copper catalyst, patterned with one electrode, enables precise placement of different DNA sequences onto a second electrode surface. The two-electrode patterning and detection platform allows for both high spatial resolution of the patterned DNA array and optimization of detection through DNA-mediated charge transport with electrocatalysis.  These platforms have been used for the successful detection of single base mismatches, specific hybridization events, and sequence-specific binding of transcription factors.  We describe the application of this two-electrode platform in the development of new cancer diagnostics.

Two electrode platforms for DNA sensing based on DNA charge transport

248th National Meeting (2014)

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