This project involves the development, synthesis and characterization of bioinorganic model complexes that mimic the active site of a biologically relevant dioxygenase enzyme, Quercetin Dioxygenase (QDO). The goal of this research is to understand how the unique active site of this enzyme cleaves the O-heteroatomic ring of quercetin by evaluating the functionality of a series of metal complexes with ligand systems similar in structure to the active site of QDO. Synthesizing biomimetic functional model complexes provides an opportunity to examine biological reactivity on a small scale through systematic and comparative studies. In addition, these new complexes can be further used in other biologically relevant synthetic transformations and applications.

Synthesis, characterization, and applicability of reactive biomimetic model complexes toward important biological reactions

248th National Meeting (2014)

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