The total synthesis of the indole alkaloid ervincidine (3) is reported. This research provides a general entry into C-6 hydroxy substituted indole alkaloids with either alpha or beta configuration. This study corrects the errors in Glasby's book and Lounasmaa's review as well as clarifies the work of Yunusov. It establishes the correct absolute configuration of the C-6 hydroxyl function in ervincidine. This serves as a structural proof and corrects the mis-assigned structure reported in the literature.

Stereospecific total synthesis of the indole alkaloid Ervincidine: Establishment of the C-6 hydroxyl stereochemistry

248th National Meeting (2014)

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